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The editor's selection of refereed research articles published recently in BMC Genomics and BMC Bioinformatics
Antiproliferative action of vitamin D
The antiproliferative effects of vitamin D on a breast tumour cell line persist despite knockdown of the vitamin D receptor gene, and variants resistant to these anti-proliferative effects do not show changes in known vitamin D signaling pathway genes.
BMC Genomics 2009, 10:499

Modeling cellcell contact
Methods for quantifying cellcell contact often rely on global descriptors, such as overall cell density, but a new statistical model that accounts for local interactions, such as individual cell-cell distances, reduces noisy data and effectively describes contact inhibition effects.
BMC Bioinformatics 2009, 10:350

Related journals
BMC Genomics
BMC Bioinformatics
BMC Systems Biology
BMC Medical Genomics
Genome Medicine
Gateways
Bioinformatics and Genomics Gateway
Microarrays Gateway
RNAi Gateway
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 Welcome to Genome Biology
  Biology for the post-genomic era.

Research    
Mammalian long noncoding RNAs
Marques AC, Ponting CP / 06 November 2009

A comparative evolutionary analysis of two mouse long noncoding RNA libraries reveals a much larger pool of noncoding RNAs remains yet to be discovered.

Protein family review   
The SR protein family
Shepard PJ, Hertel KJ / 27 October 2009

The SR proteins are not only involved in pre-mRNA splicing but in mRNA export and the initiation of translation.

Research    
Exonic splicing element evolution
Zhang Z, Zhou L, Wang P, Liu Y, Chen X, Hu L, Kong X / 02 November 2009

An analysis of human exonic splicing elements in duplicated genes reveals their important role in the generation of new gene structures.

Minireview   
Comparing cellular proteomes by mass spectrometry
Fröhlich F, Walther TC / 28 October 2009

Mass spectrometry and cryo-electron tomography together can enable absolute protein abundance to be determined.

Research    
Ras isoforms and the cell cycle
Castellano E, Guerrero C, Nunez A, De Las Rivas J, Santos E / 06 November 2009

Transcriptional and functional analysis reveals that the H-Ras and N-Ras isoforms have different roles in the initial phases of the mouse cell cycle.


Sequencing of the potato late blight pathogen Phytophthora infestans provides insight into the structure and evolution of its genome.

Research    
Transcription factor interdependence
Tomaru Y, Simon C, Forrest ARR, Miura H, Kubosaki A, Hayashizaki Y, Suzuki M / 02 November 2009

The knockdown of 78 transcription factors in differentiating human THP-1 cells using matrix RNAi reveals their interdependence

The complete issue of Genome Biology Volume 10 Issue 10 is now available.

Comment   
Petsko GA / 04 November 2009
Method    
Yavas G, Koyuturk M, Ozsoyoglu M, Gould M, LaFramboise T / 22 October 2009
Protein family review   
Rajasekharan S, Kennedy TE / 29 September 2009
Research    
Pang M, Woodward AW, Agarwal V, Guan X, Ha M, Ramachandran V, Chen X, Triplett BA, Stelly DM, Chen ZJ / 04 November 2009
Meeting report   
Munson M, Bolon DN / 27 October 2009
Method    
Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN, LeProust EM, et al. / 16 October 2009
Protein family review   
Lal-Nag M, Morin PJ / 26 August 2009
Research    
Conrad TM, Joyce AR, Applebee MK, Barrett CL, Xie B, Gao Y, Palsson BØ / 22 October 2009
Minireview   
Tatonetti NP, Liu T, Altman RB / 02 September 2009

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